Early access opening soon

From FASTQ to peaks, without waiting for a bioinformatician.

Kromla runs standard, inspectable epigenomics pipelines in the cloud. Upload your reads, describe your experiment in plain words, and get QC reports, peaks, coverage tracks and methylation calls back. You pay only for the compute you use, with no subscription and no cluster to manage.

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Runs in the EU (Finland)
Built on standard open-source tools
Prepaid credits, no surprise bills

H3K27me3 ChIP-seq · 6 samples

This is H3K27me3, so use broad peaks. Keep the input controls paired by replicate.

Done. Peak calling is now broad (MACS3, q 0.05), and each IP is paired with its own input. Estimated cost: 6 credits.

1Trim & QC fastp
2Map to hg38 bowtie2
3Filter & dedup samtools
4Call broad peaks macs3
5Coverage tracks bigWig
6Plain-language report html

How it works

Three steps, no command line.

Upload your reads

Drop in FASTQ files straight from the sequencing core. Kromla checks the files and detects adapters for you.

Describe the experiment

Tell the assistant what you are studying. It adjusts a standard pipeline, swaps tools when it makes sense, and explains every change.

Run and download

Pipelines run on autoscaling cloud compute. You get a plain-language QC report, peaks, bigWigs for the genome browser, and methylation calls.

Assays

Modular pipelines for the epigenomics you actually run.

ChIP-seq

Narrow and broad peaks, input controls, replicate handling.

MACS3 · SICER · HOMER

CUT&Tag / CUT&RUN

Peak calling tuned for sparse, low-background signal.

SEACR · MACS3

ATAC-seq

Mitochondrial read filtering and open-chromatin peak calling.

bowtie2 · BWA · MACS3

DNA methylation

WGBS, RRBS and EM-seq, from alignment to per-CpG calls.

Bismark

Every step is a module you can inspect, tune or replace, so a pipeline is never a black box.

Pricing

Pay for what you run. Nothing else.

Buy credits up front and spend them as you run. You see an estimate before every run and are charged for the compute it actually uses, and nothing starts without credit, so there are no invoices after the fact for you or your grant administrator.

No subscriptionNo seats, no minimums, no idle cluster.
Estimate firstThe cost of each run is shown before you press start.
Assistant includedDesigning and tuning pipelines with the assistant is included.

Be one of the first labs on Kromla.

We are onboarding a small group of labs for the beta. Tell us which assays you run and roughly how many samples a month.

Request early access